library compounds within the simcyp simulator Search Results


simcyp simulator  (Simcyp)
86
Simcyp simcyp simulator
Simcyp Simulator, supplied by Simcyp, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/library+compounds+within+the+simcyp+simulator/simcyp+simulator/pm42095647-326-3-3
Average 86 stars, based on 1 article reviews
simcyp simulator - by Bioz Stars, 2026-09
86/100 stars
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cardiac safety simulator calculations cardiac safety simulator css version 2 2  (Certara L.P)
86
Certara L.P cardiac safety simulator calculations cardiac safety simulator css version 2 2
Cardiac Safety Simulator Calculations Cardiac Safety Simulator Css Version 2 2, supplied by Certara L.P, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/library+compounds+within+the+simcyp+simulator/1+2+edition+professional+version+winnonlin/pm36068182-40-3-13
Average 86 stars, based on 1 article reviews
cardiac safety simulator calculations cardiac safety simulator css version 2 2 - by Bioz Stars, 2026-09
86/100 stars
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simcyp population based adme simulator  (Simcyp)
86
Simcyp simcyp population based adme simulator
Simcyp Population Based Adme Simulator, supplied by Simcyp, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/library+compounds+within+the+simcyp+simulator/adme+based+population+simcyp+simulator/pmc13148688-89-0-0
Average 86 stars, based on 1 article reviews
simcyp population based adme simulator - by Bioz Stars, 2026-09
86/100 stars
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pbpk simulator version 21  (Certara L.P)
86
Certara L.P pbpk simulator version 21
Workflow for developing the escitalopram <t>PBPK</t> model. Upward arrows denote an increase, and downward arrows denote a decrease. Abbreviations: M.W., molecular weight; LogP, logarithm of octanol/water partition coefficient; pK a , negative logarithm of acid dissociation constant; B/P, blood-to-plasma ratio; fa, fraction absorbed; k a , absorption rate constant; f u,gut , fraction unbound in gut enterocytes; Q gut , Hybrid parameter representing drug absorption rate from the gut lumen, removal of drug from the enterocyte by enterocytic blood supply, and enterocyte volume; Vss, steady-state volume of distribution; K p scalar, tissue-to-plasma partition coefficient scalar; CL int , intrinsic clearance; CYP, cytochrome P450; GFR, glomerular filtration rate; NM, normal metabolizer; PM, poor metabolizer; CL PDM , Maternal-placental barrier clearance; CL PDF , placental-fetal barrier clearance.
Pbpk Simulator Version 21, supplied by Certara L.P, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/library+compounds+within+the+simcyp+simulator/modelling+pbpk/pmc12567279-79-9-14
Average 86 stars, based on 1 article reviews
pbpk simulator version 21 - by Bioz Stars, 2026-09
86/100 stars
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simcypw simulator  (Biopharm GmbH)
90
Biopharm GmbH simcypw simulator
Workflow for developing the escitalopram <t>PBPK</t> model. Upward arrows denote an increase, and downward arrows denote a decrease. Abbreviations: M.W., molecular weight; LogP, logarithm of octanol/water partition coefficient; pK a , negative logarithm of acid dissociation constant; B/P, blood-to-plasma ratio; fa, fraction absorbed; k a , absorption rate constant; f u,gut , fraction unbound in gut enterocytes; Q gut , Hybrid parameter representing drug absorption rate from the gut lumen, removal of drug from the enterocyte by enterocytic blood supply, and enterocyte volume; Vss, steady-state volume of distribution; K p scalar, tissue-to-plasma partition coefficient scalar; CL int , intrinsic clearance; CYP, cytochrome P450; GFR, glomerular filtration rate; NM, normal metabolizer; PM, poor metabolizer; CL PDM , Maternal-placental barrier clearance; CL PDF , placental-fetal barrier clearance.
Simcypw Simulator, supplied by Biopharm GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/library+compounds+within+the+simcyp+simulator/simcypw+simulator/pm22927116-363-1-6
Average 90 stars, based on 1 article reviews
simcypw simulator - by Bioz Stars, 2026-09
90/100 stars
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population based simulator v14  (Cetara Corporation)
90
Cetara Corporation population based simulator v14
Workflow for developing the escitalopram <t>PBPK</t> model. Upward arrows denote an increase, and downward arrows denote a decrease. Abbreviations: M.W., molecular weight; LogP, logarithm of octanol/water partition coefficient; pK a , negative logarithm of acid dissociation constant; B/P, blood-to-plasma ratio; fa, fraction absorbed; k a , absorption rate constant; f u,gut , fraction unbound in gut enterocytes; Q gut , Hybrid parameter representing drug absorption rate from the gut lumen, removal of drug from the enterocyte by enterocytic blood supply, and enterocyte volume; Vss, steady-state volume of distribution; K p scalar, tissue-to-plasma partition coefficient scalar; CL int , intrinsic clearance; CYP, cytochrome P450; GFR, glomerular filtration rate; NM, normal metabolizer; PM, poor metabolizer; CL PDM , Maternal-placental barrier clearance; CL PDF , placental-fetal barrier clearance.
Population Based Simulator V14, supplied by Cetara Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/library+compounds+within+the+simcyp+simulator/population+based+simulator+v14/10__1002_slash_cpt__570-3237-5-10
Average 90 stars, based on 1 article reviews
population based simulator v14 - by Bioz Stars, 2026-09
90/100 stars
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Image Search Results


Workflow for developing the escitalopram PBPK model. Upward arrows denote an increase, and downward arrows denote a decrease. Abbreviations: M.W., molecular weight; LogP, logarithm of octanol/water partition coefficient; pK a , negative logarithm of acid dissociation constant; B/P, blood-to-plasma ratio; fa, fraction absorbed; k a , absorption rate constant; f u,gut , fraction unbound in gut enterocytes; Q gut , Hybrid parameter representing drug absorption rate from the gut lumen, removal of drug from the enterocyte by enterocytic blood supply, and enterocyte volume; Vss, steady-state volume of distribution; K p scalar, tissue-to-plasma partition coefficient scalar; CL int , intrinsic clearance; CYP, cytochrome P450; GFR, glomerular filtration rate; NM, normal metabolizer; PM, poor metabolizer; CL PDM , Maternal-placental barrier clearance; CL PDF , placental-fetal barrier clearance.

Journal: Pharmaceutics

Article Title: Escitalopram Dose Optimization During Pregnancy: A PBPK Modeling Approach

doi: 10.3390/pharmaceutics17101341

Figure Lengend Snippet: Workflow for developing the escitalopram PBPK model. Upward arrows denote an increase, and downward arrows denote a decrease. Abbreviations: M.W., molecular weight; LogP, logarithm of octanol/water partition coefficient; pK a , negative logarithm of acid dissociation constant; B/P, blood-to-plasma ratio; fa, fraction absorbed; k a , absorption rate constant; f u,gut , fraction unbound in gut enterocytes; Q gut , Hybrid parameter representing drug absorption rate from the gut lumen, removal of drug from the enterocyte by enterocytic blood supply, and enterocyte volume; Vss, steady-state volume of distribution; K p scalar, tissue-to-plasma partition coefficient scalar; CL int , intrinsic clearance; CYP, cytochrome P450; GFR, glomerular filtration rate; NM, normal metabolizer; PM, poor metabolizer; CL PDM , Maternal-placental barrier clearance; CL PDF , placental-fetal barrier clearance.

Article Snippet: The PBPK model of escitalopram was developed using Simcyp ® PBPK simulator version 21 (Certara, Princeton, NJ, USA) to simulate pharmacokinetics in nonpregnant women, pregnant women, and the fetoplacental unit. shows the overall workflow.

Techniques: Molecular Weight, Clinical Proteomics, Filtration